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Swathi Yadlapalli

Swathi Yadlapalli, Ph.D.

Associate Professor
U-M Primary Appointment
Cell & Developmental Biology
Swathi Yadlapalli, Ph.D., and her lab focuses on the neural and molecular mechanisms driving circadian rhythms, using Drosophila as a model to uncover how clock proteins, mRNA, and genes dynamically localize and regulate ~24‑hour cycles. Her team has pioneered live-cell imaging methods to show: clock proteins form membrane-less condensates at the nuclear envelope, clock genes cluster near the envelope, and specific introns in timeless mRNA are spliced at nuclear speckles—timing mechanisms essential for daily rhythms. A former HHMI and Damon Runyon postdoctoral fellow, Dr. Yadlapalli holds a Ph.D. (2013, UM Medical School), an M.S. from Yale (2008), and a B.S. from IIIT Hyderabad (2004). As a member of the Eisenberg Depression Center, she aims to translate insights from fly clocks to human health—shedding light on how circadian disruption contributes to disorders like diabetes, cancer, and neurodegeneration.
Research Focus

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