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Key Directions for Depression Center Research

Several overarching areas of depression, bipolar disorder, and related research are of special interest to Depression Center investigators. These include:

  • Underlying biological, psychosocial and stress changes that increase an individual’s risk for these illnesses
  • Ways to improve early identification, prevention of recurrences, and progression
  • The genetic underpinnings of depression and bipolar disorder
  • The relationship between sleep and depressive illnesses
  • Imaging of key neurobiological changes in the brain
  • The co-occurrence of depression with other conditions such as cancer, diabetes, cardiovascular disease, and substance abuse
  • Stress and its effects on the body, especially stress hormones and their effects on the brain
  • Suicide prevention, with a special focus on adolescents and returning veterans
  • New treatment options for patients with treatment resistant depression (TRD), including brain stimulation approaches.