K Sue O'Shea, PhD
“The work done in my lab is important since there are few replicated susceptibility genes, and no good cell or animal models, to study bipolar disorder — a disease that affects millions of people.”
Dr. O’Shea received her bachelor’s degree in Psychology and Spanish from the University of Nebraska and her Ph.D. in Developmental Biology from the University of Cambridge, England. In Cambridge, she worked in the laboratory that isolated the first embryonic stem cells from mouse embryos. Research in the University of Michigan O’Shea lab is focused on understanding the events involved in the induction and early differentiation of the nervous system using mouse models, embryonic stem cells, and induced pluripotent stem cells (iPSC). The scientists have recently identified a small RNA (ribonucleic acid) that controls the differentiation of stem cells into neurons, and are investigating its role in CNS (central nervous system) development.
Dr. O’Shea’s lab, where she directs eight researchers, is working with the Prechter Bipolar Research Fund to derive induced pluripotent stem cells (iPSC) from skin biopsies from patients diagnosed with bipolar disorder and control individuals. This exciting project involves sampling skin tissue from adults with and without the illness, and transforming those cells into stem cells and ultimately into nerve cells that look and behave like brain cells. This allows us to understand — in a laboratory — how individuals might react to different treatments and it is truly the heart of “personalized medicine.” We believe this novel research will lead to treatments based on each individual’s unique cellular profile.
Dr. O’Shea also heads the Michigan Center for Pluripotent Stem Cell Research, an NIH-funded central resource for the University of Michigan campus that helps researchers from many labs culture and work with human embryonic stem cell lines that are on the approved list for NIH-funding. They also train researchers in the derivation of induced pluripotent stem cells to model developmental disorders.